ibandronate + vitamin d

Ibandronate + vitamin D is a fixed-dose combination drug containing the bisphosphonate ibandronate and vitamin D (commonly as cholecalciferol). Ibandronate is a potent nitrogen-containing bisphosphonate that inhibits osteoclast-mediated bone resorption by targeting farnesyl pyrophosphate synthase in the mevalonate pathway. Vitamin D (cholecalciferol) is essential for calcium absorption and bone health. The combination is primarily used for the treatment of postmenopausal osteoporosis, aiming to both reduce bone resorption (via ibandronate) and correct or prevent vitamin D deficiency (via cholecalciferol), which can further support bone mineral density improvements. Clinical studies have shown that this once-monthly combination pill increases serum 25-hydroxyvitamin D levels, decreases markers of bone resorption, and improves bone mineral density in postmenopausal women with osteoporosis[1][5]. The combined formulation addresses common issues of poor compliance with separate dosing regimens for bisphosphonates and supplements[1].

Brand names

Bonviva PlusViva-DBonivaBonviva

Other names

ibandronate and cholecalciferolibandronate and vitamin d3IBN+