iBAP-II

iBAP-II is a selective small molecule inhibitor of BRCA1-associated protein-1 (BAP1), a deubiquitinating enzyme (DUB) that plays a critical role in protein stability and tumorigenesis. By inhibiting BAP1, iBAP-II prevents the deubiquitination and subsequent stabilization of the anti-apoptotic protein BIRC5 (survivin), leading to its degradation. This mechanism results in reduced cell viability, migration, and invasion in gastric cancer cells, while inducing apoptosis via the PARP and Caspase-3 pathways. Research indicates that iBAP-II can effectively sensitize 5-fluorouracil (5-FU)-resistant gastric cancer cells to chemotherapy, suggesting its potential as a combination therapy to overcome drug resistance in aggressive malignancies.