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Drug intelligence / Profile preview
Ibizol
- Development stage
- Phase 4
- Lead developer
- Megat Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Ibizol** is an oral fixed-dose combination of **ibuprofen** and **thiocolchicoside** marketed by Megat in Ecuador for short-term treatment of mild-to-moderate painful musculoskeletal conditions associated with skeletal-muscle contracture or spasm. Ibuprofen is a nonsteroidal anti-inflammatory drug that reversibly and nonselectively inhibits cyclooxygenase enzymes, reducing prostaglandin production and thereby relieving pain and inflammation. Thiocolchicoside is a centrally acting muscle relaxant that interacts with gamma-aminobutyric acid type A and strychnine-sensitive glycine receptors. Marketed coated-tablet presentations include ibuprofen 400 mg plus thiocolchicoside 4 mg and ibuprofen 600 mg plus thiocolchicoside 4 mg.
- Brand names
- Ibizol
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)GABAA (Gamma-aminobutyric acid receptor)Glycine receptor
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