ibuprofen + codeine

Ibuprofen + codeine is a fixed-dose combination analgesic containing the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen and the opioid analgesic codeine. Ibuprofen acts primarily by inhibiting cyclooxygenase (COX-1 and COX-2), thereby reducing prostaglandin synthesis, which leads to decreased inflammation, pain, and fever. Codeine is a weak opioid that exerts its effect mainly through partial metabolic conversion to morphine; it binds to mu-opioid receptors in the central nervous system, altering pain perception and response. The combination provides additive or synergistic pain relief for acute moderate pain when other non-opioid options are insufficient[3][5][10]. It is used for short-term management of mild to moderate pain such as postoperative or dental pain[3][5]. The efficacy of this combination has been demonstrated in clinical studies, though some evidence suggests it may not always be superior to ibuprofen alone[1][7].

Brand names

Nurofen Plus

Other names

ibuprofen/codeine phosphateibuprofen and codeine