ibuprofen + phenylephrine hydrochloride

Ibuprofen + phenylephrine hydrochloride is a fixed-dose combination pharmaceutical product used for the temporary relief of symptoms associated with the common cold, flu, and upper respiratory tract infections. It combines ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid derivative class, with phenylephrine hydrochloride, a sympathomimetic decongestant. Ibuprofen provides analgesic, antipyretic, and anti-inflammatory effects by non-selectively inhibiting the cyclooxygenase enzymes COX-1 and COX-2, thereby reducing the synthesis of pro-inflammatory prostaglandins. Phenylephrine hydrochloride acts as a selective alpha-1 adrenergic receptor agonist, causing vasoconstriction of the arterioles in the nasal mucosa, which leads to a reduction in swelling and congestion of the nasal passages. This combination is typically formulated as an immediate-release oral tablet and is widely available over-the-counter (OTC) in many regions, with various generic versions undergoing bioequivalence studies to match reference products like Advil Congestion Relief.