Drug intelligence / Profile preview

ibuprofen + ThermaCare heat wraps

Development stage
Unknown
Lead developer
Johnson & Johnson
Modality
Small Molecules
Administration
Oral (ibuprofen), Transdermal (ThermaCare Heat Wraps, Applied To Skin)
01

Overview

This is a **combination therapy** of the pharmaceutical drug ibuprofen and the medical device ThermaCare heat wraps, used together for the relief of musculoskeletal pain, particularly for conditions such as acute neck pain and low back pain[1][3]. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, inflammation, and fever by inhibiting cyclooxygenase (COX) enzymes, thus decreasing prostaglandin synthesis. ThermaCare heat wraps deliver continuous low-level heat (~40°C for hours), increasing blood flow locally, relaxing muscles, and accelerating tissue healing[4]. The combination aims to enhance pain control and functional improvement beyond either therapy alone by combining systemic anti-inflammatory action with local thermotherapy[1][3][4].

Other names
ibuprofen plus ThermaCare heat wrapsibuprofen + continuous low-level heatibuprofen + heat therapyibuprofen + heat wraps
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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