ibuprofen EchoG

Ibuprofen EchoG refers to a specific echocardiographically-guided dosing protocol for the treatment of patent ductus arteriosus (PDA) in preterm infants, developed by the Fundación para la Investigación Biomédica del Hospital Universitario La Paz. Unlike the standard fixed three-dose regimen (10-5-5 mg/kg), this approach utilizes serial echocardiography to determine the necessity of subsequent doses based on a ductal diameter threshold of ≥1.5 mm. Ibuprofen acts as a non-selective cyclooxygenase (COX) inhibitor, reducing prostaglandin synthesis to promote the pharmacological closure of the ductus arteriosus. This personalized strategy aims to minimize drug exposure and potential side effects in neonates without compromising efficacy.

Brand names

Intrafen

Other names

echocardiographically-guided ibuprofenEchoG ibuprofenibuprofen EchoG-Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz-patent ductus arteriosus