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ICG-PSMA
- Development stage
- Unknown
- Lead developer
- Shanghai General Hospital
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
ICG-PSMA is a targeted fluorescent imaging agent developed for the intraoperative visualization of prostate cancer. It consists of the near-infrared fluorescence (NIRF) dye indocyanine green (ICG) conjugated to a small-molecule ligand that specifically targets prostate-specific membrane antigen (PSMA), a protein highly expressed on the surface of prostate cancer cells. By binding to PSMA, the agent allows surgeons to identify tumor margins, lymph node metastases, and extracapsular extension in real-time using fluorescence-guided surgery systems. This approach is intended to improve the accuracy of radical prostatectomy, potentially leading to better oncological outcomes and improved preservation of urinary and sexual function.
- Other names
- Indocyanine Green-labeled PSMA ligandPSMA-targeted ICG-based fluorescent probe
02
Targets
PSMA (Prostate-specific membrane antigen)
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