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icilin
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Intraperitoneal, Intrathecal, Intra-cisterna Magna, Subcutaneous, Intramuscular, Topical, Oral
01
Overview
Icilin is a synthetic small molecule that functions as a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. It is known for producing an intense sensation of cold, being significantly more potent and efficacious than menthol. Beyond its primary action on TRPM8, icilin also acts as an inhibitor of the transient receptor potential V3 (TRPV3) channel and an agonist of the human epithelial Na+ channel (hENaC). Research indicates its potential involvement in various physiological processes and conditions, including migraine pathophysiology, autoimmune neuroinflammation, pruritus, colitis, and certain types of cancer, where it has shown effects such as attenuating inflammatory responses and inhibiting cancer cell motility.
- Other names
- AG 3-5AG3-5AG-3-5
02
Targets
ENaCTRPV3 (Transient receptor potential vanilloid subtype 3)TRPM4 (Calcium-activated non-selective cation channel TRPM4)
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