Drug intelligence / Profile preview

ICM-203

Development stage: Phase 2
Lead developer: ICM
Modality: AAV Vectors → Viral Vectors → Gene Addition/Replacement → Gene Therapies
Administration: Intraarticular

Overview

ICM-203 is a **recombinant adeno-associated viral (AAV) vector-based gene therapy** designed as a **disease-modifying osteoarthritis drug (DMOAD)**. It is engineered to express a therapeutic gene after intra-articular injection, aiming to **promote cartilage formation, reduce joint inflammation and pain, and improve joint physical function** in patients with osteoarthritis. The vector likely modulates specific targets involved in cartilage biology; one reported mechanism involves modulation of **NKX3-2**, a transcription factor implicated in cartilage formation and maintenance. The drug is being developed for osteoarthritis and rheumatoid arthritis, and is currently in phase 1/2 clinical trials for osteoarthritis. The developer is ICM (also referenced as ICM Biotech and ICM Co. Ltd.)[1][3][4][6][7].

Other names: ICM-203ICM203ICM 203

Beyond the preview

Go deeper on ICM-203.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on ICM-203.

Explore the full profile