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iCM012
- Development stage
- Phase 3
- Lead developer
- iCoat Medical
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Ex Vivo
01
Overview
iCM012 is a modified polymer-based biologic developed by iCoat Medical AB to prevent ischemia-reperfusion injury (IRI) during organ transplantation. It utilizes a proprietary coating technology that allows the polymer to integrate into cell membranes, creating a protective barrier. This barrier prevents the binding of plasma proteins and the activation of the innate immune system (specifically the complement and coagulation systems) against ischemic cells. Its primary application is currently in kidney transplantation, specifically for recipients of donation after circulatory death (DCD) kidneys, to reduce the incidence of delayed graft function (DGF).
- Other names
- iCM012 solution 2 mg/mL
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