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ICM20 + benznidazole
- Development stage
- Unknown
- Lead developer
- IC-MedTech
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
ICM20 + benznidazole is a combination drug evaluated for the treatment of Chagas disease, an infection caused by the parasite *Trypanosoma cruzi*. ICM20 is a distinct investigational agent, though its precise mechanism of action is not publicly disclosed. Benznidazole is a well-established trypanocidal agent whose mechanism involves the reduction by parasitic nitroreductases to electrophilic metabolites that damage proteins, lipids, DNA, and RNA within the parasite, leading to cell death. The combination is in early-phase clinical development to assess safety, tolerability, and potential additive or synergistic therapeutic effects in adults with serologically confirmed Chagas disease[1][7].
- Brand names
- ICM20 + benznidazole
- Other names
- ICM20 + benznidazole
02
Targets
kDNA (Kinetoplast DNA)NTR (Bacterial nitroreductase)
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