icodextrin + amino acids + Physioneal

This drug is a **combination peritoneal dialysis solution** comprising three primary components: **icodextrin**, **amino acids**, and a solution branded as **Physioneal**. - **Icodextrin** is a glucose polymer used as an osmotic agent to facilitate sustained ultrafiltration and sodium removal during long peritoneal dialysis dwells, functioning via colloid osmosis[1][3][4]. - **Amino acids** are included in the dialysis solution to provide nutritional support, serving as a source of essential nutrients for patients, and partially substituting for glucose to reduce peritoneal glucose exposure[1][5]. - **Physioneal** is a brand of peritoneal dialysis (PD) solution that contains a mixture of electrolytes and is formulated to be biocompatible, often using a bicarbonate/lactate buffer system to minimize local and systemic toxicity to the peritoneal membrane. The mechanism involves **osmotic removal of water and solutes (icodextrin, amino acids, Physioneal)** via the peritoneum, aiming at effective ultrafiltration, sodium balance, reduced glucose load, and enhanced patient nutrition[1][3]. This combination is especially considered for nocturnal automated peritoneal dialysis (APD), optimizing fluid and solute removal while minimizing cumulative glucose exposure[1][3][5].

Brand names

PhysionealExtranealNutrineal

Other names

icodextrin + amino acids + Physioneal