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ICON-1 + aflibercept
- Development stage
- Discontinued
- Lead developer
- Endpoint Health
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Intravitreal
01
Overview
ICON-1 + aflibercept is an investigational combination therapy for neovascular (wet) age-related macular degeneration (AMD), composed of ICON-1, an anti-Tissue Factor (TF) fusion protein, and aflibercept, a recombinant fusion protein acting as a decoy receptor for vascular endothelial growth factor (VEGF). ICON-1 specifically targets pathologic vessels overexpressing TF, inhibiting abnormal choroidal neovascularization (CNV) and exudation, while aflibercept blocks VEGF-driven angiogenesis by binding VEGF-A, VEGF-B, and placental growth factor (PlGF), preventing their interaction with endogenous receptors. The combination aims for synergistic disease modification, improved visual acuity, and more durable outcomes by acting on different mechanisms related to neovascularization and fluid exudation[3][5].
- Other names
- ICON-1 + afliberceptICON-1 and afliberceptICON1 and afliberceptICON 1 and afliberceptICON-1 with afliberceptICON1 with afliberceptICON 1 with aflibercept
02
Targets
PGF (Placental Growth Factor)VEGFA (Vascular endothelial growth factor A)VEGFB (Vascular endothelial growth factor B)F3 (Tissue factor)
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