Drug intelligence / Profile preview

ICP-001

Development stage
Preclinical
Lead developer
ICaPath
Modality
Cytokines & Interferons → Recombinant Proteins and Enzymes, Nanoparticles → Drug Delivery Systems
01

Overview

**ICP-001** is an investigational ICaPath cancer immunotherapy consisting of recombinant human interleukin-12 encapsulated in poly(lactic-co-glycolic acid) nanoparticles. The PLGA carrier is designed to provide prolonged, controlled release of very low doses of IL-12, aiming to activate antitumor T-cell and natural killer-cell responses through the interleukin-12 receptor while reducing the systemic toxicity historically associated with IL-12 therapy. The program is being developed preclinically for advanced cancers, including osteosarcomas and pleomorphic neoplastic diseases. ([icapath.com](https://icapath.com/))

Other names
IL-12 encapsulated in PLGA nanoparticlesIL12 encapsulated in PLGA nanoparticlesIL 12 encapsulated in PLGA nanoparticlesIL12+PLGAinterleukin-12 + poly(lactic-co-glycolic acid)rHu-IL-12 + PLGA nanoparticles
02

Targets

IL-12R (Interleukin-12 receptor)

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