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ICTCAR-CRC
- Development stage
- Preclinical
- Lead developer
- Innovative Cellular Therapeutics
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
ICTCAR-CRC is an autologous chimeric antigen receptor (CAR) T-cell therapy being developed by SiDanSai Biotechnology (ICT) for the treatment of colorectal cancer. The therapy utilizes the proprietary CoupledCAR® technology, which incorporates a second signaling component designed to promote the expansion and survival of CAR-T cells within the challenging immunosuppressive environment of solid tumors. ICTCAR-CRC specifically targets Guanylyl Cyclase C (GCC), a transmembrane cell surface receptor that is highly expressed in the majority of metastatic colorectal cancers but has restricted expression in normal tissues. The program is currently in the IND-enabling stage.
- Other names
- ICTCAR-CRC (CoupledCAR®)
02
Targets
GUCY2C (Guanylate cyclase C receptor)
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