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ICTP-201

Development stage: Preclinical
Lead developer: InnoCure Therapeutics
Modality: PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
Administration: Oral

Overview

ICTP-201 is a preclinical-stage, orally bioavailable proteolysis-targeting chimera (PROTAC) developed by InnoCure Therapeutics. It is designed for the treatment of NUT midline carcinoma (NMC), T-cell acute lymphoblastic leukemia (T-ALL), and various c-Myc-related solid tumors. The drug utilizes InnoCure's proprietary MILPROTAC (Minimizing Linker PROTAC) technology platform, which is engineered to enhance oral absorption by optimizing the linker between the target-binding and E3 ligase-binding moieties. ICTP-201 specifically targets the BRD4-NUT fusion protein for degradation by recruiting the cereblon (CRBN) E3 ubiquitin ligase, thereby leveraging the ubiquitin-proteasome system to eliminate the oncogenic driver protein.

Targets

BRD4 (Bromodomain-containing protein 4)CRBN (Cereblon)BRD4-NUT (Bromodomain-containing protein 4-Nuclear protein in testis fusion protein)

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