Drug intelligence / Profile preview

Icy Hot Pro-Therapy

Development stage
Unknown
Lead developer
Chattem
Modality
Small Molecules
Administration
Topical
01

Overview

Icy Hot Pro-Therapy is a high-strength topical analgesic formulation developed for the temporary relief of minor aches and pains associated with arthritis, simple backache, muscle strains, sprains, and bruises. Unlike the standard Icy Hot formulations that typically combine menthol and methyl salicylate, the Pro-Therapy line utilizes a potent combination of menthol (16%) and camphor (11%). These active ingredients function as counterirritants; menthol targets the TRPM8 receptors to induce a cooling sensation, while camphor interacts with TRPV receptors to produce a warming effect and increase local blood flow. This dual-action sensory stimulation desensitizes nociceptive pathways and provides a competitive stimulus that distracts the central nervous system from underlying musculoskeletal pain. It is marketed as a professional-grade over-the-counter solution for athletes and individuals with chronic joint or muscle discomfort.

Brand names
Icy Hot Pro-TherapyIcy Hot Pro
Other names
Menthol 16% + Camphor 11% Topical
02

Targets

TRPV1 (Transient receptor potential cation channel subfamily V member 1)TRPM8 (Transient receptor potential cation channel subfamily M member 8)TRPV3 (Transient receptor potential vanilloid subtype 3)

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