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IDC2404
- Development stage
- Preclinical
- Lead developer
- Prestige Biopharma
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Subcutaneous
01
Overview
IDC2404 is a monoclonal antibody biosimilar developed by Prestige Biopharma (PBK) that targets the alpha4beta7 integrin. It is designed as a biosimilar to vedolizumab (Entyvio) for the treatment of inflammatory bowel diseases, including ulcerative colitis and Crohn's disease. By binding to the alpha4beta7 integrin on the surface of circulating memory T lymphocytes, IDC2404 inhibits the interaction of these cells with mucosal addressin cell adhesion molecule-1 (MAdCAM-1) on the vascular endothelium of the gastrointestinal tract. This mechanism prevents the migration of inflammatory cells into the gut mucosa, thereby reducing local inflammation. The drug is currently in the preclinical stage of development.
- Other names
- vedolizumab biosimilar
02
Targets
α4β7 (Integrin alpha-4 beta-7 heterodimer)
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