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IdeZ
- Development stage
- Preclinical
- Modality
- Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
IdeZ is a recombinant IgG-cleaving cysteine protease derived from *Streptococcus equi* subsp. *zooepidemicus* that specifically cuts immunoglobulin G below the hinge region, rapidly generating F(ab')2 and Fc fragments and thereby transiently eliminating functional circulating IgG. It has primarily been used as a research reagent for antibody fragmentation and analytical characterization, and it has also been investigated preclinically as an immune-debulking approach to overcome pre-existing anti-AAV neutralizing antibodies and enable adeno-associated virus gene transfer. Unlike imlifidase, which is the clinically developed IgG-cleaving enzyme from *Streptococcus pyogenes*, IdeZ itself does not appear to be an approved therapeutic product.
- Other names
- IgG-degrading enzyme ZIdeZ proteaseImmunoglobulin G-degrading enzyme Z
02
Targets
IgG hinge (Immunoglobulin G hinge region)
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