IDN 5243

**IDN 5243** is a novel small molecule new chemical entity (NCE) derived semisynthetically from botanical origins through collaboration between Indena and major Italian universities. It exhibits potent **muscle-relaxant** activity, significant **anti-inflammatory** effects (e.g., in carrageenin-induced edema and granuloma models at 10 mg/kg intraperitoneally), and **analgesic** properties, positioning it as a candidate for **musculoskeletal pain** treatment. The molecule, chemically a **3-glycosyl-3-O-demethylthiocolchicine derivative** synthesized from D-xylose and 3-O-demethylthiocolchicine, demonstrated good tolerability in preclinical toxicology studies and was planned for Phase I trials in healthy volunteers around late 2006; a Phase 2 trial for low back pain was initiated but later withdrawn.[1][3][7]

Other names

3-glycosyl-3-O-demethylthiocolchicine3-glycosyl-3-O-demethylthiocolchicine derivative