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ido1 short hairpin rna
- Development stage
- Preclinical
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intramuscular, Topical
01
Overview
IDO1 short hairpin RNA (IDO1 shRNA) is an experimental RNA interference (RNAi) therapeutic designed to silence the expression of indoleamine 2,3-dioxygenase 1 (IDO1). IDO1 is a rate-limiting enzyme in the tryptophan catabolism pathway that facilitates immune evasion by depleting tryptophan and producing kynurenine in the tumor microenvironment. By knocking down IDO1 expression, this shRNA modality aims to restore antitumor immunity, enhance neutrophil infiltration, and increase interferon-gamma levels. Preclinical studies have explored its use in various malignancies, including ovarian, bladder, and lung cancers, often delivered via plasmid or viral vectors to sensitize tumors to chemotherapy or enhance immune-mediated tumor suppression.
- Other names
- indoleamine 2,3-dioxygenase 1 short hairpin RNA
02
Targets
IDO1 (Indoleamine 2,3-dioxygenase 1)
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