Drug intelligence / Profile preview

IDP-120 Component B

Development stage
Unknown
Lead developer
Ortho Dermatologics
Modality
Hydrogel Systems → Drug Delivery Systems, Small Molecules
Administration
Topical
01

Overview

IDP-120 is a fixed-dose combination topical gel developed for the treatment of moderate to severe acne vulgaris. The formulation consists of two components, with "Component B" specifically referring to one part of this admixture. According to patent documentation, IDP-120 is an admixture by weight of two components; however, the precise composition of "Component B" is not explicitly detailed in public sources. The overall product (IDP-120) contains benzoyl peroxide and tretinoin as active ingredients[6][7]. Benzoyl peroxide acts as an antibacterial and keratolytic agent, while tretinoin is a retinoid that modulates epithelial cell growth and differentiation. The mechanism involves reducing Propionibacterium acnes colonization, decreasing inflammation, and promoting skin cell turnover.

02

Targets

RARB (Retinoic acid receptor beta)RARA (Retinoic acid receptor alpha)RARG (Retinoic acid receptor gamma)

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