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Idursulfase beta
- Development stage
- Phase 3
- Lead developer
- GC Biopharma
- Modality
- Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Idursulfase beta is a recombinant form of the human enzyme iduronate-2-sulfatase, used as an enzyme replacement therapy for patients with mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome. It works by replacing the deficient iduronate-2-sulfatase enzyme in affected individuals, thereby reducing the accumulation of glycosaminoglycans (GAGs) that cause the symptoms of MPS II. Idursulfase beta is produced in Chinese hamster ovary cells using a serum-free medium and has been shown to have higher enzymatic activity and faster cellular uptake compared to other forms of iduronate-2-sulfatase. The drug is administered intravenously and marketed under the brand name Hunterase[1][3][6][8].
- Brand names
- Hunterase
- Other names
- Idursulfase βIdursulfase beta Injection
02
Targets
IDS (Iduronate-2-sulfatase)
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