IEM 1460

**IEM 1460** is a synthetic small molecule, specifically an adamantane derivative, that acts as a **competitive, selective, and voltage-dependent open-channel blocker of AMPA-type glutamate receptors, particularly those lacking the GluR2 (GluA2) subunit, making them Ca2+-permeable"[1][3][5][7][9]. It can also block NMDA receptor-mediated currents at higher concentrations[1][7][3]. Used primarily for research, IEM 1460 is a valuable pharmacological tool for identifying and targeting Ca2+-permeable AMPA receptors, especially within certain neuron populations (e.g., fast-spiking GABAergic interneurons)[1][5][7]. It displays anticonvulsant properties in animal models and has been used experimentally to probe synaptic plasticity and neuroprotective mechanisms, but is not approved for clinical or veterinary use[1][3][7].

Brand names

IEM 1460IEM1460IEM-1460

Other names

N,N,N-Trimethyl-5-[(tricyclo[3.3.1.1 3,7]dec-1-ylmethyl)amino]-1-pentanaminium bromide hydrobromide