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iG-Tregs
- Development stage
- Phase 2
- Lead developer
- University of Patras
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
iG-Tregs (induced GvHD-specific regulatory T cells) is an investigational adoptive cell therapy developed by the University of Patras for the prevention and treatment of graft-versus-host disease (GvHD) following hematopoietic stem cell transplantation. The therapy consists of donor-derived CD4+ T cells that are induced ex vivo into a regulatory T cell (Treg) phenotype, characterized by the expression of the transcription factor FOXP3. The induction process typically utilizes a specialized culture protocol involving TGF-beta and pharmacological agents like rapamycin to generate a stable and functional suppressive cell population. These induced Tregs are designed to suppress the activation and proliferation of alloreactive donor T cells that attack host tissues, thereby mitigating GvHD while potentially preserving the beneficial graft-versus-tumor effect.
- Other names
- induced regulatory T cellsinduced GvHD-specific regulatory T cellsinduced GvHD-specific Tregs
02
Targets
NeuraminidaseHLA-G (Human leukocyte antigen G)IL-2 (Interleukin 2)
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