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IG101
- Development stage
- Preclinical
- Lead developer
- Ingenium Therapeutics
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Parenteral
01
Overview
IG101 is a preclinical-stage Target Immune Stimulator (TIS) candidate being developed by Ingenium Therapeutics for the treatment of solid tumors. Built on Ingenium's proprietary TIS platform, IG101 is a bispecific antibody-linker-payload conjugate designed to overcome the limitations of conventional antibody-drug conjugates (ADCs) and immunotherapies. It utilizes a bispecific antibody targeting receptor tyrosine kinase-like orphan receptor 1 (ROR1) to selectively localize to tumor cells, delivering an immune-stimulating payload such as an IL-21/IL-15 fusion cytokine or the TN13 peptide (a p38 inhibitor) to modulate the tumor microenvironment and activate local immune cells.
02
Targets
ROR1 (Receptor tyrosine kinase-like orphan receptor 1)
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