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iGC101

Development stage: Preclinical
Lead developer: Shanghai Juncell Therapeutics
Modality: CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intravenous

Overview

iGC101 is a preclinical-stage mRNA-based Chimeric Antigen Receptor (CAR) Natural Killer (NK) cell therapy being developed by JunCell. This therapeutic approach involves the transient expression of CARs on NK cells using mRNA transfection, which is designed to enhance the cells' ability to target and eliminate solid tumor cells while potentially offering a safer profile compared to viral-based CAR therapies due to the non-integrative nature of mRNA. The specific target of the CAR in iGC101 is not publicly disclosed in the provided context, but the program is positioned for the treatment of various solid tumors.

Targets

Patient-specific tumor neoantigen-HLA complex

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