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Drug intelligence / Profile preview
igermetostat + cyclophosphamide + doxorubicin + vincristine + etoposide + prednisone
- Development stage
- Phase 2
- Lead developer
- Evopoint Biosciences
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
XNW5004 + CHOEP is a combination regimen consisting of the novel EZH2 inhibitor igermetostat (XNW5004) and the standard chemotherapy backbone CHOEP (cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone). Igermetostat is a selective, substrate-competitive small molecule inhibitor of Enhancer of Zeste Homolog 2 (EZH2), which is the catalytic subunit of the polycomb repressive complex 2 (PRC2) responsible for histone H3 lysine 27 (H3K27) methylation. Developed by Evopoint Biosciences, this combination is primarily being evaluated for the treatment of patients with newly diagnosed peripheral T-cell lymphoma (PTCL). The regimen aims to combine the epigenetic modulating effects of igermetostat with the cytotoxic activity of the CHOEP regimen to improve outcomes in untreated PTCL patients.
- Other names
- Igermetostat + CHOEP
02
Targets
EZH2 (Histone-lysine N-methyltransferase EZH2)DNATOP2A (DNA topoisomerase II)GR (Glucocorticoid receptor)TUBB (Tubulin (alpha and beta subunits))
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