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IGN101
- Development stage
- Unknown
- Lead developer
- Symphogen
- Modality
- Vaccines & Immunotherapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Subcutaneous
01
Overview
IGN101 is an active cancer vaccine composed of the murine monoclonal antibody edrecolomab (17-1A) adsorbed onto aluminum hydroxide. It targets the Epithelial Cell Adhesion Molecule (EpCAM), a protein highly expressed in approximately 70% of epithelial cancers, including colorectal, rectal, and lung tumors. The vaccine is designed to stimulate the patient's immune system to produce an anti-idiotypic antibody response (Ab2) and a subsequent anti-anti-idiotypic response (Ab3) that recognizes and attacks EpCAM-expressing tumor cells. Developed by Igeneon (a subsidiary of Aphton), IGN101 was evaluated in several clinical trials for epithelial malignancies. However, a large Phase II/III trial in patients with non-small cell lung cancer (NSCLC) failed to demonstrate a survival benefit, leading to the cessation of its development for that indication.
- Other names
- edrecolomabMab17-1AMab-17-1AMab 17-1A17-1A
02
Targets
EPCAM (Epithelial cell adhesion molecule)
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