IGUANA-1

IGUANA-1 is a potent and highly selective small molecule inhibitor of aldehyde dehydrogenase 1B1 (ALDH1B1), an enzyme implicated in the growth and maintenance of colorectal cancer cells and organoids. IGUANA-1 demonstrates strong antitumor activity in preclinical models with minimal mitochondrial toxicity, distinguishing it from related compounds. Molecular studies confirm that IGUANA-1 binds the active site of ALDH1B1 and inhibits its function at nanomolar concentrations. IGUANA-1 is used as a tool compound in cancer research and has not been reported to be in clinical trials or approved for human therapeutic use[1][3][5][7][9].

Other names

IGUANA-1IGUANA1IGUANA 1STL5-T-0057STL-5-T-0057STL 5-T-0057