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IH-2022 consolidation therapy
- Development stage
- Unknown
- Lead developer
- Institute of Hematology and Blood Diseases Hospital
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Intravenous, Oral, Intrathecal
01
Overview
IH-2022 consolidation therapy is a multi-agent chemotherapy regimen developed by the Institute of Hematology & Blood Diseases Hospital, China, for the treatment of adult patients with Philadelphia chromosome-negative (Ph-negative) acute lymphoblastic leukemia (ALL). This regimen is part of a pediatric-inspired protocol (IH-2022) and consists of a combination of vincristine, daunorubicin, cyclophosphamide, pegaspargase, prednisone, dexamethasone, cytarabine, 6-mercaptopurine, and high-dose methotrexate. It is typically administered following induction therapy to eliminate residual leukemia cells and reduce the risk of relapse. In current clinical trials, this consolidation phase is often evaluated in combination with targeted agents like venetoclax and immunotherapies such as blinatumomab to improve minimal residual disease (MRD) negativity and event-free survival.
- Other names
- consolidation therapy-Institute of Hematology & Blood Diseases Hospital, China-acute lymphoblastic leukemiaConsolidation therapy (IH-2022)Pediatric-inspired consolidation chemotherapy
02
Targets
TOP2A (DNA topoisomerase II)TUBB (Tubulin (alpha and beta subunits))DHFR (Dihydrofolate reductase)DNA polymerase familyGR (Glucocorticoid receptor)DNA
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