IH636 grape seed proanthocyanidin extract

IH636 grape seed proanthocyanidin extract is a standardized extract from the seeds of *Vitis vinifera* containing oligomeric proanthocyanidins (OPCs), a class of polyphenolic flavonoids. It is recognized for its potent **antioxidant**, **free-radical scavenging**, and **chemoprotective properties**. IH636 has shown the ability to inhibit the growth of certain cancer cells while promoting the viability of normal cells[1][4][6]. Mechanistically, its effects are proposed to involve scavenging of free radicals, inhibition of lipid peroxidation and DNA fragmentation, and modulation of apoptotic and survival gene expression (including upregulation of bcl-Xs and JNK, and downregulation of bcl-Xl)[1][4]. It has demonstrated cardioprotective effects, including reduction of atherosclerotic lesions and serum cholesterol in animal models, and may reduce oxidative stress-mediated vascular injury[2][4][5]. Clinical studies and dietary supplement monographs describe use for symptoms of chronic venous insufficiency and as a general antioxidant[3][5].

Brand names

IH636 grape seed proanthocyanidin extractIH-636 grape seed proanthocyanidin extractIH 636 grape seed proanthocyanidin extract

Other names

grape seed proanthocyanidin extractGSPEgrape seed extractVitis vinifera seed extract