II-B08

II-B08 is a small molecule inhibitor targeting several protein tyrosine phosphatases (PTPs), including SHP2, SHP1, PTP1B, FAP1, CD45, LMWPTP, and Lyp. It acts as a reversible and non-competitive inhibitor, showing 2.6- to 5.7-fold selectivity for SHP2 over related phosphatases. II-B08 is primarily used in phosphorylation and dephosphorylation research, and is effective in blocking hyperproliferative activity of hematopoietic progenitor cells and c-kit-dependent myeloid proliferation. This agent is investigated for potential utility in myeloproliferative disease models associated with c-kit or SHP2 mutations, and is used in combination studies with PI-3K inhibitors to prolong survival in preclinical models[1][9].

Brand names

II-B08II-B-08II-B 08

Other names

II-B08II-B-08II-B 08PTP Inhibitor XXXICD45 Inhibitor VCD-45 Inhibitor VCD 45 Inhibitor VFAP1 InhibitorFAP-1 InhibitorFAP 1 InhibitorLMWPTP InhibitorLyp Inhibitor IIIPTP1B Inhibitor IXPTP-1B Inhibitor IXPTP 1B Inhibitor IXSHP1 Inhibitor IXSHP-1 Inhibitor IXSHP 1 Inhibitor IXSHP2 Inhibitor VISHP-2 Inhibitor VISHP 2 Inhibitor VI3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid