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IIT-ATLG-47
- Development stage
- Unknown
- Lead developer
- Neovii Pharmaceuticals
- Modality
- Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
IIT-ATLG-47 is an investigator-initiated clinical program sponsored by Neovii Pharmaceuticals, currently in Phase 1 development for patients undergoing stem cell transplantation (SCT). The program utilizes Neovii's anti-T-lymphocyte globulin (ATLG), which is a rabbit-derived polyclonal antibody preparation. ATLG is designed to deplete T-lymphocytes and modulate immune responses, primarily to prevent graft-versus-host disease (GvHD) and facilitate successful engraftment during hematopoietic stem cell transplantation. By targeting a broad range of T-cell surface antigens, the therapy induces immunosuppression through mechanisms such as complement-dependent cytotoxicity, opsonization, and apoptosis of T-cells.
- Other names
- anti-T-lymphocyte globulinATLGanti-human T-lymphocyte globulin (rabbit)
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