Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
IK-412
- Development stage
- Discontinued
- Lead developer
- ImageneBio
- Modality
- Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes
01
Overview
IK-412 (also known as KYN 412 or "Kynase") is a novel enzyme replacement therapy and kynurenine modulator that was developed by Ikena Oncology (formerly Kyn Therapeutics) for the treatment of cancer. The drug acts as a highly potent and stable kynurenine-degrading enzyme, designed to lower levels of immunosuppressive kynurenine in the tumor microenvironment, potentially overcoming resistance to immune-modulating agents such as checkpoint inhibitors. Its mechanism involves enzymatic degradation of kynurenine, an immunosuppressive metabolite implicated in cancer progression and immune evasion. Development was conducted in partnership with Bristol Myers Squibb but has since been discontinued at the preclinical stage for oncology indications[1][3][4][7].
- Brand names
- Kynase
- Other names
- IK 412IK412IK-412KYN 412KYN412KYN-412kynase
Beyond the preview
Go deeper on IK-412.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on IK-412.