Drug intelligence / Profile preview

IKC-151V

Development stage: Preclinical
Lead developer: ikarovec
Modality: AAV Vectors → Viral Vectors → Gene Addition/Replacement → Gene Therapies
Administration: Intravitreal, Ophthalmic

Overview

IKC-151V is a gene therapy drug developed by Ikarovec Ltd. It is a bi-cistronic vector designed to treat retinal conditions associated with significant vascular remodeling, particularly wet age-related macular degeneration (wet-AMD). The drug has demonstrated the ability to reverse neovascularization in murine AMD models. Research suggests that IKC-151V gene therapy can reverse vascular changes occurring during neovascular AMD (nAMD), with findings indicating that connective tissue growth factor (CTGF) plays a role in its mechanism of action. The drug is currently in preclinical development stage.

Targets

FCGR1A (High affinity immunoglobulin gamma fc receptor I)CTGF (Connective tissue growth factor)VEGFA (Vascular endothelial growth factor A)FCGRT (Neonatal crystallizable fragment receptor)

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