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IKKb matured Dendritic Cells
- Development stage
- Unknown
- Lead developer
- University Hospital Erlangen
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
A personalized cellular immunotherapy consisting of autologous monocyte-derived dendritic cells that are matured through activation of the NF-κB pathway via IKKb (IκB kinase beta) and loaded with tumor RNA. The therapy involves three types of RNA: amplified tumor mRNA, RNA encoding driver mutations, and RNA encoding overexpressed non-mutated tumor antigens. This approach aims to stimulate both T cells and NK cells to create a coordinated immune response against cancer.
- Other names
- IKKβ-matured RNA-transfected dendritic cellsIKKβ-matured Dendritic CellsDC IKKb
02
Targets
IL-12R (Interleukin-12 receptor)γδ TCR (T-cell receptor)CD28 (Cluster of Differentiation 28)
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