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IL-10 XX CAR-T
- Development stage
- Preclinical
- Lead developer
- Leman Biotech
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
IL-10 XX CAR-T is an investigational chimeric antigen receptor (CAR) T-cell therapy being developed by Leman Bio for the treatment of solid tumors. The therapy utilizes Leman's proprietary Meta 10 platform, which involves armoring CAR-T cells with a metabolic modulator based on Interleukin-10 (IL-10). This engineering is intended to enhance the metabolic fitness of the T cells, promote the formation of oxidative phosphorylation-dependent memory stem cells, and overcome the immunosuppressive tumor microenvironment, thereby preventing T-cell exhaustion. While the specific tumor-associated antigen (XX) targeted by this candidate is currently undisclosed, the program is in the IND-enabling phase with first-in-human trials projected for early 2026.
- Other names
- IL-10-armored XX CAR-TIL10-armored XX CAR-TIL 10-armored XX CAR-T
02
Targets
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