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IL-13Rα2 UCAR-T cell injection
- Development stage
- Unknown
- Lead developer
- Zhongshan People's Hospital
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous, Intratumoral
01
Overview
IL-13Rα2 UCAR-T cell injection is an allogeneic, universal chimeric antigen receptor T-cell (UCAR-T) therapy designed to target the interleukin-13 receptor alpha 2 (IL-13Rα2). IL-13Rα2 is a cell-surface protein that is highly overexpressed in the majority of high-grade gliomas, including glioblastoma, but is absent or expressed at very low levels in normal brain tissue, making it a promising therapeutic target. As a universal CAR-T product, these cells are derived from healthy donors and engineered to minimize graft-versus-host disease (GvHD) and host-mediated rejection, allowing for an off-the-shelf treatment model. The therapy is currently being investigated in Phase 1 clinical trials for the treatment of advanced glioma to assess its safety, persistence, and preliminary efficacy.
- Other names
- IL-13Rα2-targeted allogeneic UCAR-T cell injection
02
Targets
IL13RA2 (Interleukin-13 receptor subunit alpha 2)
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