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IL-15-tSC-NK complexes

Development stage: Preclinical
Lead developer: Anhui Medical University
Modality: CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Stem Cell Therapies → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous, Subcutaneous, Intraperitoneal, Intramuscular, Intratumoral, Intradermal, Intra-arterial, Intravesical, Inhalation, Oral, Rectal, Transdermal, Parenteral, Implant

Overview

**IL-15-tSC-NK complexes** are an investigational, preclinical engineered cell therapy comprising natural killer cells bioorthogonally conjugated to tumor-tropic adipose-derived mesenchymal stem cells that have been transiently engineered with lipid nanoparticle-delivered IL-15 mRNA. The mesenchymal stem-cell carrier promotes tumor localization, while locally produced interleukin-15 supports NK-cell survival, activation, infiltration, and cytotoxic function within the tumor microenvironment. The construct showed antitumor activity in orthotopic murine lung-cancer and patient-derived xenograft ovarian-cancer models, and its activity was enhanced by Galectin-9 blockade in the reported preclinical studies. ([advanced.onlinelibrary.wiley.com](https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202509638))

Other names: IL-15-tSC-NKIL15-tSC-NKIL 15-tSC-NK

Targets

IL15RA (Interleukin-15 receptor subunit alpha)

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