IL-1R1 neutralizing antibody

IL-1R1 neutralizing antibody is a monoclonal antibody that binds to the Interleukin-1 receptor type 1 (IL-1R1), thereby blocking the signaling of both IL-1α and IL-1β. This inhibition prevents the activation of downstream inflammatory cascades and the NLRP3 inflammasome pathway. In preclinical research, such as the study of preeclampsia (PE) using the Reduced Uterine Perfusion Pressure (RUPP) rat model, IL-1R1 neutralization has been shown to reduce maternal hypertension, improve fetal and placental weights, and increase maternal immunotolerant regulatory T cells. While several clinical-stage candidates have targeted this receptor (e.g., AMG 108, MEDI-8968), the term is frequently used to describe research-grade reagents used in experimental models of inflammatory and hypertensive disorders.

Other names

anti-IL-1R1 antibodyanti-IL1R1 antibodyanti-IL 1R1 antibodyIL-1 receptor type 1 neutralizing antibodyIL1 receptor type 1 neutralizing antibodyIL 1 receptor type 1 neutralizing antibodyIL-1R1 inhibitorIL1R1 inhibitorIL 1R1 inhibitor