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IL-2 gene-transduced allogeneic neuroblastoma cells
- Development stage
- Unknown
- Lead developer
- St. Jude Children's Research Hospital
- Modality
- Vaccines & Immunotherapeutics, Cell Therapies, Gene Therapies
- Administration
- Subcutaneous
01
Overview
IL-2 gene-transduced allogeneic neuroblastoma cells is an experimental cell-based immunotherapy developed by St. Jude Children's Research Hospital for the treatment of relapsed or refractory neuroblastoma. The therapy consists of allogeneic (donor-derived) neuroblastoma tumor cells that have been genetically modified using retroviral gene transfer to express and secrete human interleukin-2 (IL-2). Functioning as a cancer vaccine, the IL-2-secreting tumor cells are designed to stimulate a potent anti-tumor immune response, particularly by enhancing the activity of cytotoxic T lymphocytes and natural killer cells against neuroblastoma-specific antigens. This biologic therapy was evaluated in Phase I clinical trials where it was administered via subcutaneous injection to induce a local, polyclonal T-cell infiltrate and systemic anti-tumor immunity.
- Other names
- IL-2 gene-modified allogeneic neuroblastoma cellsIL2 gene-modified allogeneic neuroblastoma cellsIL 2 gene-modified allogeneic neuroblastoma cellsInterleukin-2-transduced neuroblastoma vaccineInterleukin2-transduced neuroblastoma vaccineInterleukin 2-transduced neuroblastoma vaccineIL-2 secreting allogeneic neuroblastoma cellsIL2 secreting allogeneic neuroblastoma cellsIL 2 secreting allogeneic neuroblastoma cells
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