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IL-2-transfected CIK cells (Humboldt University)
- Development stage
- Unknown
- Lead developer
- Humboldt-Universität zu Berlin
- Modality
- Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
IL-2-transfected CIK cells are an autologous adoptive cell therapy developed by researchers at the Humboldt University of Berlin. This approach involves harvesting a patient's peripheral blood mononuclear cells and expanding them ex vivo into cytokine-induced killer (CIK) cells—a heterogeneous population of immune effectors with T-cell and NK-cell properties. These cells are then genetically modified via electroporation with a plasmid containing the interleukin-2 (IL-2) gene. The resulting cells produce IL-2 (ranging from 330-1800 pg/10^6 cells/24h), which acts in an autocrine and paracrine manner to enhance their proliferation and tumor-specific cytotoxic activity. Administered intravenously, this therapy has been investigated in Phase I trials for metastatic renal cell carcinoma, metastatic colorectal cancer, and lymphoma, showing a favorable safety profile and potential clinical activity, including a complete response in a lymphoma patient.
- Other names
- IL-2-transfected cytokine-induced killer cellsIL2-transfected cytokine-induced killer cellsIL 2-transfected cytokine-induced killer cellsAutologous IL-2-transfected CIK cellsIL-2-transfected CIK cellsIL2-transfected CIK cellsIL 2-transfected CIK cells
02
Targets
IL-2R (Interleukin-2/interleukin-15 receptor complex)LFA-1 (Integrin αLβ2)NKG2D (Natural killer group 2 member D receptor)CD226 (DNAX accessory molecule 1)NKG2DL (NKG2D ligand family)
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