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IL-33 cytokine trap
- Development stage
- Preclinical
- Lead developer
- AstraZeneca
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intranasal, Intraperitoneal, Subcutaneous
01
Overview
IL-33 cytokine trap is a recombinant fusion protein developed by AstraZeneca (originally MedImmune) that acts as a decoy receptor to neutralize interleukin-33 (IL-33). It is designed by fusing the extracellular domains of the IL-33 receptor ST2 (interleukin-1 receptor-like 1) and its co-receptor IL-1RAcP (interleukin-1 receptor accessory protein) to the Fc portion of human IgG1. By trapping IL-33, it prevents the cytokine from binding to its functional cell-surface receptor complex, thereby blocking downstream pro-inflammatory signaling cascades. It is primarily utilized as a preclinical research tool to investigate the role of the IL-33/ST2 pathway in inflammatory and autoimmune diseases, such as spondyloarthritis, asthma, and pulmonary fibrosis.
- Other names
- IL-33 trapIL33 trapIL 33 trapIL-33R-FcIL33R-FcIL 33R-FcIL33iIL-33iIL 33i
02
Targets
FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)IL33 (IL-33)IL1RAP (Interleukin 1 receptor accessory protein)
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