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IL-5R alpha siRNA
- Development stage
- Preclinical
- Lead developer
- Chungbuk National University
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Subcutaneous
01
Overview
IL-5R alpha siRNA is a small interfering RNA designed to silence the expression of the interleukin-5 receptor alpha (IL-5RA) subunit. In research settings, specifically in bladder cancer cell lines like HT1376, it has been used to demonstrate that the IL-5/IL-5R alpha signaling axis promotes cell migration through the ERK1/2-mediated expression of MMP-9 and activation of NF-κB. By knocking down the receptor, researchers observed a significant reduction in these metastatic markers, suggesting a potential role for IL-5R alpha in cancer progression beyond its traditional role in eosinophil biology.
- Other names
- IL-5RA siRNAIL5RA siRNAIL 5RA siRNAinterleukin-5 receptor alpha siRNAinterleukin5 receptor alpha siRNAinterleukin 5 receptor alpha siRNAsmall interfering RNA targeting IL-5R alpha
02
Targets
IL5RA (Interleukin-5 receptor subunit alpha)
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