Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
IL13Rα2 CAR-T cells secreting anti-PD-L1 antibody
- Development stage
- Phase 1
- Lead developer
- Ming Yang
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
01
Overview
**IL13Rα2 CAR-T cells secreting anti-PD-L1 antibody** is an investigational, autologous engineered T-cell therapy being evaluated in a phase 1 investigator-initiated study for recurrent malignant glioma. The product uses CAR-T cells directed to interleukin-13 receptor alpha-2, a glioma-associated surface antigen, and is engineered to secrete an anti-PD-L1 antibody intended to counter PD-L1-mediated immunosuppression in the tumor microenvironment. The registered study evaluates safety, cytokine-release syndrome, tumor response, progression-free survival, and overall survival. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07481721))
- Other names
- IL13Rα2 CAR-T cells secreting anti-PD-L1 antibody
02
Targets
IL13RA2 (Interleukin-13 receptor subunit alpha 2)CD274 (Programmed cell death protein 1 ligand 1)
Beyond the preview
Go deeper on IL13Rα2 CAR-T cells secreting anti-PD-L1 antibody.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on IL13Rα2 CAR-T cells secreting anti-PD-L1 antibody.