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IL15NP
- Development stage
- Preclinical
- Lead developer
- Huazhong University of Science and Technology
- Modality
- Recombinant Proteins and Enzymes, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
IL15NP is an experimental nanoparticle-based formulation of human recombinant interleukin-15 (IL-15). It consists of IL-15 protein encapsulated within PEG-PLGA-COOH nanoparticles. The drug is designed to treat acute myeloid leukemia (AML) by inducing the expression of ISG15 and upregulating MHC class I molecules (HLA-ABC) on leukemia cells. This mechanism enhances the immunogenicity of the cancer cells, promoting a graft-versus-leukemia (GVL) effect while potentially minimizing graft-versus-host disease (GVHD) when used in the context of allogeneic hematopoietic stem cell transplantation. Research indicates that IL15NP can be further modified with anti-CD33 antibodies (CD33-IL15NP) to achieve targeted delivery to CD33-positive AML cells.
- Other names
- IL-15 encapsulated nanoparticlesIL15 encapsulated nanoparticlesIL 15 encapsulated nanoparticlesPEG-PLGA-COOH nanoparticles encapsulating human recombinant IL-15 protein
02
Targets
IL-15R (Interleukin 15 receptor alpha/interleukin 15 complex)
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