ilex rotunda thunb

Ilex rotunda Thunb, commonly known as Kurogane holly, is a botanical species whose bark extract (Ilicis Rotundae Cortex) is utilized for its anti-inflammatory and antimicrobial properties. In clinical applications, particularly within the oral care industry in China, it is formulated into dentifrices to manage dental plaque and gingivitis. The extract's therapeutic efficacy is attributed to its rich content of triterpenoids, such as rotundic acid and pedunculoside, which inhibit the production of pro-inflammatory cytokines (e.g., TNF-alpha, IL-6) and modulate the NF-kappaB signaling pathway. Research conducted by institutions like Sun Yat-sen University has validated its clinical benefits in reducing gingival inflammation and plaque accumulation in adult populations.

Other names

Ilicis Rotundae CortexKurogane hollyWan Jie Cha