ilomastat

Ilomastat is a synthetic small molecule and a broad-spectrum inhibitor of matrix metalloproteinases (MMPs), including MMP-1 (interstitial collagenase), MMP-2, MMP-3, and MMP-9[1][2][3][5]. It belongs to the hydroxamic acid class of reversible metallopeptidase inhibitors. Ilomastat acts by binding the catalytic zinc ion in the active site of MMPs in a bidentate manner, thereby blocking substrate access and inhibiting enzymatic activity[3][5]. This mechanism underlies its anti-scarring effects observed in preclinical models for ophthalmic surgery (such as glaucoma filtration surgery) and other tissue remodeling conditions[4][7]. Ilomastat has also demonstrated anti-tumor and anti-angiogenic properties in experimental settings[4][5], as well as potential applications for trauma healing and corneal repair. It remains an experimental compound without regulatory approval for any indication.

Brand names

Galardin

Other names

GM6001GM-6001GM 6001galardinilomastat